Voltage-sensitive Na+ channels: motifs, modes and modulation.

Current opinion in cell biology ·Vol. 3 ·No. 4 ·1991-08-00 ·Pages 676-84

Stephan M, Agnew WS

Abstract

Much recent progress has been made in understanding the structural organization and functional properties of voltage-dependent Na+ channels, in particular in the areas of activation, ion conductance, and inactivation. At the same time, however, electrophysiological studies have revealed new, more complex functional properties in the form of at least two gating modes and the existence of as yet unidentified modulatory factors.

MeSH Terms

Action Potentials Animals Binding Sites DNA/genetics Drosophila melanogaster/genetics Eels/genetics Genes Glycosylation Humans Ion Channel Gating/physiology Mammals/genetics Models, Biological Models, Molecular Molecular Structure Neurotoxins/metabolism Oocytes Organ Specificity Protein Conformation Protein Processing, Post-Translational RNA/genetics RNA, Complementary Recombinant Proteins/metabolism Repetitive Sequences, Nucleic Acid Sequence Homology, Nucleic Acid Sodium/metabolism Sodium Channels/genetics,physiology Xenopus laevis

Chemicals

Neurotoxins RNA, Complementary Recombinant Proteins Sodium Channels RNA DNA Sodium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Stephan M

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Agnew W S

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/0955-0674(91)90041-v

Published

1991-08-00

Pages

676-84

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/0955-0674(91)90041-v View journal details

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