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PMID: 17224921 Published · ppublish English Journal Article Review

RNA viruses: hijacking the dynamic nucleolus.

Nature reviews. Microbiology ·Vol. 5 ·No. 2 ·2007-02-00 ·Pages 119-27

Hiscox JA

Abstract

The nucleolus is a dynamic subnuclear structure with roles in ribosome subunit biogenesis, mediation of cell-stress responses and regulation of cell growth. The proteome and structure of the nucleolus are constantly changing in response to metabolic conditions. RNA viruses interact with the nucleolus to usurp host-cell functions and recruit nucleolar proteins to facilitate virus replication. Investigating the interactions between RNA viruses and the nucleolus will facilitate the design of novel anti-viral therapies, such as recombinant vaccines and therapeutic molecular interventions, and also contribute to a more detailed understanding of the cell biology of the nucleolus.

MeSH Terms
Animals Cell Nucleolus/ultrastructure,virology Humans Nuclear Proteins/metabolism RNA Virus Infections/drug therapy,physiopathology,virology RNA Viruses/pathogenicity,physiology Viral Proteins/metabolism Virus Replication
Chemicals
Nuclear Proteins Viral Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hiscox Julian A
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, and Astbury Centre for Structural Molecular Biology, Garstang Building, University of Leeds, Leeds, LS2 9JT, UK. j.a.hiscox@leeds.ac.uk
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Article Info
Journal
Nature reviews. Microbiology
Abbr.
Nat Rev Microbiol
ISSN
1740-1534
DOI
10.1038/nrmicro1597
Email
j.a.hiscox@leeds.ac.uk
Published
2007-02-00
Pages
119-27
Language
English
Region
England
NLM ID
101190261
PMCID
PMC7097444
Subset
IM
Grants
Biotechnology and Biological Sciences Research Council · BBS/B/03416 · United Kingdom
External Links
PubMed source DOI: 10.1038/nrmicro1597 PMC Full Text View journal details
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