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PMID: 1722327 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 24 ·1991-12-15 ·Pages 11344-8

De Koninck Y, Henry JL

Abstract

The original proposal that substance P is involved in the regulation of nociceptive information at the first sensory synapse in the spinal cord has been substantiated by a wide range of evidence, but definitive support has been lacking, due primarily to the lack of evidence that a specific nociceptive response in the dorsal horn can be blocked by a substance P antagonist. Here, we present evidence that CP-96,345, a specific substance P (NK-1) receptor antagonist, selectively blocks a slow, prolonged excitatory postsynaptic potential following noxious cutaneous stimulation or a train of intense electrical stimuli to sensory nerves but does not affect the response to innocuous input or the brief response to single electrical stimuli to C fibers. These results indicate the specific involvement of substance P in the mediation of a prolonged after-excitation to noxious stimulation. This may have important implications for the etiology and treatment of chronic pain and for plastic changes in nociceptive pathways.

MeSH Terms
Animals Biphenyl Compounds/pharmacology Cats Evoked Potentials/drug effects Ganglia, Spinal/physiology Neurons/drug effects,physiology Nociceptors/physiology Pain/physiopathology Receptors, Neurokinin-1 Receptors, Neurotransmitter/antagonists & inhibitors,physiology Spinal Cord/physiology,physiopathology Substance P/physiology Synapses/drug effects,physiology Time Factors Touch
Chemicals
Biphenyl Compounds Receptors, Neurokinin-1 Receptors, Neurotransmitter Substance P CP 96345
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
De Koninck Y
Department of Physiology, McGill University, Montréal, Québec, Canada.
Henry J L
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36 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.24.11344
Published
1991-12-15
Pages
11344-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC53131
Subset
IM
Grants
Canadian Institutes of Health Research · 13460 · Canada
External Links
PubMed source DOI: 10.1073/pnas.88.24.11344 PMC Full Text View journal details
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