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PMID: 17202296 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Towards systems biology of human pulmonary fibrosis.

Proceedings of the American Thoracic Society ·Vol. 4 ·No. 1 ·2007-01-00 ·Pages 85-91

Studer SM, Kaminski N

Abstract

The integrated effect of multiple pathways, molecules, genetic polymorphisms, environmental stimuli, and possible infection determines the lung phenotype in idiopathic pulmonary fibrosis (IPF), a chronic progressive and often lethal lung disease. Systems biology approaches aim to provide a systemwide view of biological process using computational tools and high-throughput technologies. Although much of the analysis of genome-level transcriptional high-resolution profiles of IPF was reductionist, usually focusing on a single factor in the disease process, there are some studies that implement systems approaches. We discuss these analyses and provide examples of the global analysis of IPF, hypersensitivity pneumonitis, and nonspecific interstitial pneumonia. Detailed quantitative phenotyping and correlation with microarray results as well as high-throughput genotyping should provide us with the datasets to implement systems biology approaches in fibrosis research. Interdisciplinary teams and training of junior investigators in the vocabulary of systems biology should allow us to use these datasets integratively and generate a global model of human pulmonary fibrosis.

MeSH Terms
Animals Disease Models, Animal Genome Haplotypes Humans Mice Oligonucleotide Array Sequence Analysis Phenotype Pulmonary Fibrosis/genetics,physiopathology Rats Systems Biology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Studer Sean M
Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Kaminski Naftali
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Article Info
Journal
Proceedings of the American Thoracic Society
Abbr.
Proc Am Thorac Soc
ISSN
1546-3222
DOI
10.1513/pats.200607-139JG
Published
2007-01-00
Pages
85-91
Language
English
Region
United States
NLM ID
101203596
PMCID
PMC2647618
Subset
IM
Grants
NHLBI NIH HHS · HL073745 · United States
External Links
PubMed source DOI: 10.1513/pats.200607-139JG PMC Full Text
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