To die or not to die: a HAT trick.

Molecular cell ·Vol. 24 ·No. 6 ·2006-12-28 ·Pages 807-8

Tyteca S, Legube G, Trouche D

Abstract

In this issue of Molecular Cell, two manuscripts (Sykes et al., 2006) propose that the decision to undergo apoptosis upon DNA damage is mediated through acetylation of p53 within its DNA-binding domain by MYST histone acetyltransferases.

MeSH Terms

Acetylation Animals Apoptosis Apoptosis Regulatory Proteins/metabolism Cell Cycle Cyclin-Dependent Kinase Inhibitor p21/metabolism Histone Acetyltransferases/metabolism,physiology Humans Lysine Acetyltransferase 5 Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-mdm2/metabolism Transcriptional Activation Tumor Suppressor Protein p53/metabolism p300-CBP Transcription Factors/physiology

Chemicals

Apoptosis Regulatory Proteins BBC3 protein, human CDKN1A protein, human Cyclin-Dependent Kinase Inhibitor p21 Proto-Oncogene Proteins Tumor Suppressor Protein p53 Histone Acetyltransferases KAT5 protein, human KAT8 protein, human Lysine Acetyltransferase 5 p300-CBP Transcription Factors MDM2 protein, human Proto-Oncogene Proteins c-mdm2

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Tyteca Sandrine

LBME, CNRS and Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse, France.

Legube Gaëlle

Trouche Didier

Article Info

Journal

Molecular cell

Abbr.

Mol Cell

ISSN

1097-2765

DOI

10.1016/j.molcel.2006.12.005

Published

2006-12-28

Pages

807-8

Language

English

Region

United States

NLM ID

9802571

Subset

Corrections

CommentOn

PMID: 17189186

CommentOn

PMID: 17189187

External Links

PubMed source DOI: 10.1016/j.molcel.2006.12.005 View journal details

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