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题目:: Ex vivo expansion of human cord blood hematopoietic progenitor cells using glutaraldehyde-fixed human bone marrow stromal cells.
作者:: Ito(Yoshihiro),Hasauda(Hirokazu),Kitajima(Takashi),Kiyono(Toru)
状态:: 发布时间2006-12-25 , 更新时间 2013-11-21
期刊:: J Biosci Bioeng
摘要:: Human stromal cells were immortalized and fixed with glutaraldehyde to support an ex vivo expansion of human cord blood hematopoietic progenitor cells. In addition, this enabled glutaraldehyde-fixed stromal cells to be stored at 4 degrees C. Although freeze-dried glutaraldehyde-fixed stromal cells did not increase the number of the progenitor cells, the percent decrease in the number of CD34(+) cells in the presence of freeze-dried glutaraldehyde-fixed stromal cells was less than that in the absence of the stromal cells. Thus, glutaraldehyde-fixed stromal cells can serve as a stabilizing device for hematopoietic cell expansion.
语言:: eng
DOI:: 10.1263/jbb.102.467

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