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PMID: 17188686 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Sequestosome 1/p62--more than just a scaffold.

FEBS letters ·Vol. 581 ·No. 2 ·2007-01-23 ·Pages 175-9

Seibenhener ML, Geetha T, Wooten MW

Abstract

The interaction of proteins with ubiquitin receptors is key to solving the mystery that surrounds the functional role ubiquitin chains play in directing traffic. The specificity of these interactions is largely mediated by UbL/UBA domains. Sequestosome 1/p62 is a protein that is gaining attention as it is intimately involved in cell signaling, receptor internalization, and protein turnover. Herein we review recent advances in the field.

MeSH Terms
Adaptor Proteins, Signal Transducing Humans Protein Structure, Tertiary Proteins/chemistry,genetics,metabolism Sequestosome-1 Protein Ubiquitin/metabolism
Chemicals
Adaptor Proteins, Signal Transducing Proteins SQSTM1 protein, human Sequestosome-1 Protein Ubiquitin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Seibenhener M Lamar
Department of Biological Sciences, Program in Cellular and Molecular Biosciences, 331 Funchess Hall, Auburn University, Auburn, AL 36849, United States.
Geetha Thangiah
Wooten Marie W
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Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/j.febslet.2006.12.027
Published
2007-01-23
Epub
2006-00-19
Pages
175-9
Language
English
Region
England
NLM ID
0155157
PMCID
PMC1850379
Subset
IM
Grants
NINDS NIH HHS · R01 NS033661-07A2 · United States
External Links
PubMed source DOI: 10.1016/j.febslet.2006.12.027 PMC Full Text View journal details
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