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PMID: 17187981 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Reproduction and longevity: secrets revealed by C. elegans.

Trends in cell biology ·Vol. 17 ·No. 2 ·2007-02-00 ·Pages 65-71

Mukhopadhyay A, Tissenbaum HA

Abstract

What is the relationship between reproduction and longevity? Evolutionary biology suggests that reproduction exacts a cost in somatic maintenance, a cost that reduces longevity. The frequent occurrence of this tradeoff between life span and fecundity, both due to experimental manipulations as well as natural variation, suggest that the mechanism might be conserved during evolution. Until recently, little was known about the mechanistic details of how reproduction might regulate life span. Here we discuss recent advances in our understanding of the regulation of life span by reproductive signaling, focusing on studies using Caenorhabditis elegans.

MeSH Terms

Aging/physiology Animals Caenorhabditis elegans/cytology,embryology,genetics,growth & development,physiology Caenorhabditis elegans Proteins/genetics,physiology Cell Lineage Disorders of Sex Development Forkhead Transcription Factors Gene Expression Regulation, Developmental Genitalia/embryology,growth & development Germ Cells/cytology,radiation effects Gonads/embryology,growth & development,physiology Insulin/physiology Insulin-Like Growth Factor I/physiology Intestines/physiology Intracellular Signaling Peptides and Proteins/physiology Longevity/genetics,physiology Models, Biological Receptor, Insulin/physiology Receptors, Transforming Growth Factor beta/physiology Reproduction/genetics,physiology Signal Transduction/physiology Transcription Factors/physiology Transforming Growth Factor beta/physiology

Chemicals

Caenorhabditis elegans Proteins Forkhead Transcription Factors Insulin Intracellular Signaling Peptides and Proteins KRI-1 protein, C elegans Receptors, Transforming Growth Factor beta Transcription Factors Transforming Growth Factor beta daf-16 protein, C elegans Insulin-Like Growth Factor I DAF-2 protein, C elegans Receptor, Insulin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Mukhopadhyay Arnab

Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School 364 Plantation Street, Worcester, MA 01605, USA.

Tissenbaum Heidi A

Article Info

Journal

Trends in cell biology

Abbr.

Trends Cell Biol

ISSN

1879-3088

DOI

10.1016/j.tcb.2006.12.004

Published

2007-02-00

Epub

2006-00-21

Pages

65-71

Language

English

Region

England

NLM ID

9200566

Subset

External Links

PubMed source DOI: 10.1016/j.tcb.2006.12.004 View journal details

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