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题目:: Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins.
作者:: Woetmann(Anders),Lovato(Paola),Eriksen(Karsten W),Krejsgaard(Thorbjørn),Labuda(Tord),Zhang(Qian),Mathiesen(Anne-Merethe),Geisler(Carsten),Svejgaard(Arne),Wasik(Mariusz A),Ødum(Niels)
状态:: 发布时间2007-04-05 , 更新时间 2016-10-19
期刊:: Blood
摘要:: Bacterial toxins including staphylococcal enterotoxins (SEs) have been implicated in the pathogenesis of cutaneous T-cell lymphomas (CTCLs). Here, we investigate SE-mediated interactions between nonmalignant T cells and malignant T-cell lines established from skin and blood of CTCL patients. The malignant CTCL cells express MHC class II molecules that are high-affinity receptors for SE. Although treatment with SE has no direct effect on the growth of the malignant CTCL cells, the SE-treated CTCL cells induce vigorous proliferation of the SE-responsive nonmalignant T cells. In turn, the nonmalignant T cells enhance proliferation of the malignant cells in an SE- and MHC class II-dependent manner. Furthermore, SE and, in addition, alloantigen presentation by malignant CTCL cells to irradiated nonmalignant CD4(+) T-cell lines also enhance proliferation of the malignant cells. The growth-promoting effect depends on direct cell-cell contact and soluble factors such as interleukin-2. In conclusion, we demonstrate that SE triggers a bidirectional cross talk between nonmalignant T cells and malignant CTCL cells that promotes growth of the malignant cells. This represents a novel mechanism by which infections with SE-producing bacteria may contribute to pathogenesis of CTCL.
语言:: eng
DOI:

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