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PMID: 17174464 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Binding of intrinsically disordered proteins is not necessarily accompanied by a structural transition to a folded form.

Biochimie ·Vol. 89 ·No. 3 ·2007-03-00 ·Pages 419-21

Sigalov AB, Zhuravleva AV, Orekhov VY

Abstract

There are a large number of protein domains and even entire proteins, lacking ordered structure under physiological conditions. Intriguingly, a highly flexible, random coil-like conformation is the native and functional state for many proteins known to be involved in cell signaling. An example is a key component of immune signaling, the cytoplasmic region of the T cell receptor zeta subunit. This domain exhibits specific dimerization that is distinct from non-specific aggregation behavior seen in many systems. In this work, we use diffusion and chemical shift mapping NMR data to show that the protein does not undergo a transition between disordered and ordered states upon dimerization. This finding opposes the generally accepted view on the behavior of intrinsically disordered proteins, provides evidence for the existence of specific dimerization interactions for intrinsically disordered protein species and opens a new line of research in this new and quickly developing field.

MeSH Terms
Dimerization Nuclear Magnetic Resonance, Biomolecular Protein Binding Protein Folding Protein Structure, Tertiary Proteins/chemistry
Chemicals
Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sigalov Alexander B
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. alexander.sigalov@umassmed.edu
Zhuravleva Anastasia V
Orekhov Vladislav Yu
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11 references, click to expand
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Article Info
Journal
Biochimie
Abbr.
Biochimie
ISSN
0300-9084
Published
2007-03-00
Epub
2006-00-22
Pages
419-21
Language
English
Region
France
NLM ID
1264604
PMCID
PMC2692994
Subset
IM
Grants
NIAID NIH HHS · P30 AI042845 · United States
NIAID NIH HHS · P30 AI042845-08 · United States
NIAID NIH HHS · P30 AI42845-08 · United States
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