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题目:: Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.
作者:: Castellone(Maria Domenica),Teramoto(Hidemi),Gutkind(J Silvio)
状态:: 发布时间2006-12-05 , 更新时间 2015-08-13
期刊:: Cancer Res
摘要:: Colorectal cancer poses a major clinical challenge in the developed world where this disease is common. Recent findings suggest that the prostaglandin E(2), the proinflammatory product of elevated cyclooxygenase-2 activity in colon cancer, stimulates cancer cell growth through a G protein-dependent signaling pathway coupling the prostaglandin EP2 receptor to beta-catenin control. These findings provide new insights into the molecular framework needed to evaluate chemopreventive strategies for colorectal cancer.
语言:: eng
DOI:: 10.1158/0008-5472.CAN-06-2233

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