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PMID: 17145717 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

DisProt: the Database of Disordered Proteins.

Nucleic acids research ·Vol. 35 ·No. Database issue ·2007-01-00 ·Pages D786-93

Sickmeier M, Hamilton JA, LeGall T, Vacic V, Cortese MS, Tantos A, Szabo B, Tompa P, Chen J, Uversky VN, Obradovic Z, Dunker AK

Abstract

The Database of Protein Disorder (DisProt) links structure and function information for intrinsically disordered proteins (IDPs). Intrinsically disordered proteins do not form a fixed three-dimensional structure under physiological conditions, either in their entireties or in segments or regions. We define IDP as a protein that contains at least one experimentally determined disordered region. Although lacking fixed structure, IDPs and regions carry out important biological functions, being typically involved in regulation, signaling and control. Such functions can involve high-specificity low-affinity interactions, the multiple binding of one protein to many partners and the multiple binding of many proteins to one partner. These three features are all enabled and enhanced by protein intrinsic disorder. One of the major hindrances in the study of IDPs has been the lack of organized information. DisProt was developed to enable IDP research by collecting and organizing knowledge regarding the experimental characterization and the functional associations of IDPs. In addition to being a unique source of biological information, DisProt opens doors for a plethora of bioinformatics studies. DisProt is openly available at http://www.disprot.org.

MeSH Terms
Databases, Protein Internet Protein Conformation Protein Folding Proteins/physiology User-Computer Interface
Chemicals
Proteins
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Sickmeier Megan
Department of Biochemistry and Molecular Biology, Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Hamilton Justin A
LeGall Tanguy
Vacic Vladimir
Cortese Marc S
Tantos Agnes
Szabo Beata
Tompa Peter
Chen Jake
Uversky Vladimir N
Obradovic Zoran
Dunker A Keith
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
1362-4962
DOI
10.1093/nar/gkl893
Published
2007-01-00
Epub
2006-00-01
Pages
D786-93
Language
English
Region
England
NLM ID
0411011
PMCID
PMC1751543
Subset
IM
Grants
Wellcome Trust · United Kingdom
NLM NIH HHS · R01 LM007688 · United States
Wellcome Trust · 067595 · United Kingdom
NLM NIH HHS · R01 LM007688-01A1 · United States
External Links
PubMed source DOI: 10.1093/nar/gkl893 PMC Full Text View journal details
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