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题目:: The stem cell continuum: considerations on the heterogeneity and plasticity of marrow stem cells.
作者:: Quesenberry(Peter J),Dooner(G),Dooner(M),Colvin(G)
状态:: 发布时间2006-11-29 , 更新时间 2009-12-11
期刊:: Stem Cell Rev
摘要:: Traditional models of hematopoiesis have been hierarchical. Recent evidence showing that marrow stem cells are a cycling population and that the hematopoietic phenotype of these cells reversibly changes with cycle transit have suggested a continuum model of stem cell regulators. Studies on marrow cell conversion to lung cells have extended this continuum to cycle-related differentiation into nonhematopoietic stem cells. We postulate that stem cells transiting cell cycle continually change their chromatin structure, thus providing different windows of transcriptional opportunity and a continually changing phenotype. Final outcomes with this continuum model would be determined by the specific chromatin state of the cell and the presence of specific differentiation inducers.
语言:: eng
DOI:: 10.1385/SCR:1:1:029

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