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PMID: 17129739 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase.

Neurobiology of learning and memory ·Vol. 87 ·No. 3 ·2007-03-00 ·Pages 372-84

Hu D, Cao P, Thiels E, Chu CT, Wu GY, Oury TD, Klann E

Abstract

Superoxide has been shown to be critically involved in several pathological manifestations of aging animals. In contrast, superoxide also can act as a signaling molecule to modulate signal transduction cascades required for hippocampal synaptic plasticity. Mitochondrial superoxide dismutase (SOD-2 or Mn-SOD) is a key antioxidant enzyme that scavenges superoxide. Thus, SOD-2 may not only prevent aging-related oxidative stress, but may also regulate redox signaling in young animals. We used transgenic mice overexpressing SOD-2 to study the role of mitochondrial superoxide in aging, synaptic plasticity, and memory-associated behavior. We found that overexpression of SOD-2 had no obvious effect on synaptic plasticity and memory formation in young mice, and could not rescue the age-related impairments in either synaptic plasticity or memory in old mice. However, SOD-2 overexpression did decrease mitochondrial superoxide in hippocampal neurons, and extended the lifespan of the mice. These findings increase our knowledge of the role of mitochondrial superoxide in physiological and pathological processes in the brain.

MeSH Terms
Analysis of Variance Animals Hippocampus/enzymology Long-Term Potentiation/physiology Longevity/physiology Memory/physiology Mice Mice, Transgenic Mitochondria/enzymology Superoxide Dismutase/metabolism
Chemicals
Superoxide Dismutase superoxide dismutase 2
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Hu Daoying
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
Cao Peng
Thiels Edda
Chu Charleen T
Wu Gang-Yi
Oury Tim D
Klann Eric
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Article Info
Journal
Neurobiology of learning and memory
Abbr.
Neurobiol Learn Mem
ISSN
1074-7427
DOI
10.1016/j.nlm.2006.10.003
Published
2007-03-00
Epub
2006-00-28
Pages
372-84
Language
English
Region
United States
NLM ID
9508166
PMCID
PMC1847321
Subset
IM
Grants
NINDS NIH HHS · R01 NS034007 · United States
NINDS NIH HHS · R01 NS047384 · United States
NINDS NIH HHS · NS047384 · United States
NHLBI NIH HHS · R01 HL063700 · United States
NINDS NIH HHS · R37 NS034007 · United States
NINDS NIH HHS · R29 NS034007 · United States
NHLBI NIH HHS · HL63700 · United States
NINDS NIH HHS · NS034007 · United States
External Links
PubMed source DOI: 10.1016/j.nlm.2006.10.003 PMC Full Text View journal details
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