Triggering the brain's pathology sensor.

Nature neuroscience ·Vol. 9 ·No. 12 ·2006-12-00 ·Pages 1463-4

Kettenmann H

Abstract

Microglia, the brain's intrinsic immune cells, rapidly sense brain injury and help clear cellular debris. Haynes et al. now show that P2Y12 receptors are critical for activating microglia and directing them to the site of injury.

MeSH Terms

Animals Brain/immunology,pathology Brain Diseases/immunology,pathology Brain Injuries/immunology,pathology Humans Microglia/immunology,physiology Receptors, Purinergic P2/physiology Receptors, Purinergic P2Y12

Chemicals

P2RY12 protein, human Receptors, Purinergic P2 Receptors, Purinergic P2Y12

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Kettenmann Helmut

Max Delbrück Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13082 Berlin, Germany. kettenmann@mdc-berlin.de

Article Info

Journal

Nature neuroscience

Abbr.

Nat Neurosci

ISSN

1097-6256

DOI

10.1038/nn1206-1463

kettenmann@mdc-berlin.de

Published

2006-12-00

Pages

1463-4

Language

English

Region

United States

NLM ID

9809671

Subset

Corrections

CommentOn

PMID: 17115040

External Links

PubMed source DOI: 10.1038/nn1206-1463 View journal details

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Triggering the brain's pathology sensor.

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