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PMID: 17122907 Published · ppublish English Historical Article Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

The story of Bioglass.

Journal of materials science. Materials in medicine ·Vol. 17 ·No. 11 ·2006-11-00 ·Pages 967-78

Hench LL

Abstract

Historically the function of biomaterials has been to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasses were discovered in 1969 and provided for the first time an alternative; second generation, interfacial bonding of an implant with host tissues. Tissue regeneration and repair using the gene activation properties of Bioglass provide a third generation of biomaterials. This article reviews the 40 year history of the development of bioactive glasses, with emphasis on the first composition, 45S5 Bioglass, that has been in clinical use since 1985. The steps of discovery, characterization, in vivo and in vitro evaluation, clinical studies and product development are summarized along with the technology transfer processes.

MeSH Terms
Cell Cycle/physiology Ceramics/history History, 20th Century History, 21st Century Osteoblasts/cytology
Chemicals
Bioglass
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hench Larry L
Department of Materials and Tissue Engineering and Regenerative Medicine Centre, Imperial College London, Prince Consort Road, London, SW7 2AZ.
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50 references, click to expand
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Article Info
Journal
Journal of materials science. Materials in medicine
Abbr.
J Mater Sci Mater Med
ISSN
0957-4530
DOI
10.1007/s10856-006-0432-z
Published
2006-11-00
Epub
2006-00-22
Pages
967-78
Language
English
Region
United States
NLM ID
9013087
Subset
IM
External Links
PubMed source DOI: 10.1007/s10856-006-0432-z View journal details
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