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PMID: 1712241 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Fast atom bombardment mass spectrometric analysis of arginine-containing neuropeptides.

Biomedical & environmental mass spectrometry ·Vol. 19 ·No. 13 ·1990-12-20 ·Pages 819-21

Silberring J, Nyberg F

Abstract

A new procedure using fast atom bombardment mass spectrometry for the determination of arginine residues in neuropeptides is described. The technique is based on the modification of the arginine side-group with 1,2-cyclohexanedione. This novel procedure may have a potential use in the study of neuropeptides and their processing and degrading enzymes.

MeSH Terms

Amino Acid Sequence Dynorphins/chemistry Molecular Sequence Data Neuropeptides/chemistry Oligopeptides/chemistry Peptide Fragments/chemistry Spectrometry, Mass, Fast Atom Bombardment Substance P/chemistry

Chemicals

Neuropeptides Oligopeptides Peptide Fragments dynorphin B (5-9) Substance P substance P (1-7) Dynorphins tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-arginine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Silberring J

Department of Pharmacology, University of Uppsala, Sweden.

Nyberg F

Article Info

Journal

Biomedical & environmental mass spectrometry

Abbr.

Biomed Environ Mass Spectrom

ISSN

0887-6134

DOI

10.1002/bms.1200191305

Published

1990-12-20

Pages

819-21

Language

English

Region

England

NLM ID

8603224

Subset

External Links

PubMed source DOI: 10.1002/bms.1200191305

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