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PMID: 17122049 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 26 ·No. 47 ·2006-11-22 ·Pages 12242-50

Cafferty WB, Strittmatter SM

Abstract

The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies. However, genetic assessment of the role of Nogo-A in corticospinal tract (CST) axons after spinal cord dorsal hemisection has yielded conflicting results. CST regeneration is detected in homozygous nogo-ab(trap/trap) mice, but not in nogo-ab(atg/atg) mice. CST regeneration is also present after pharmacological NgR blockade, but not in ngr1(-/-) mice. To assess the nogo-ab(atg) and ngr1-null alleles for other axon growth phenotypes, we created unilateral pyramidotomies and monitored the uninjured CST. There is robust pyramidotomy-induced growth of nogo-ab(atg/atg) and ngr1(-/-) CST axons into denervated cervical gray matter. This fiber growth correlates with recovery of fine motor skill in the affected forelimb. Thus nogo-ab and ngr1 play a modulated role in limiting CNS axonal growth across a spectrum of different tracts in various lesion models.

MeSH Terms
Analysis of Variance Animals Axons/physiology Behavior, Animal Calcitonin Gene-Related Peptide/metabolism Central Nervous System/cytology Functional Laterality Glial Fibrillary Acidic Protein/metabolism Mice Mice, Inbred C57BL Mice, Knockout Myelin Basic Protein/metabolism Myelin Proteins/metabolism Nogo Proteins Protein Kinase C/metabolism Psychomotor Performance/physiology Pyramidal Tracts/injuries,metabolism,physiology Receptors, Peptide/deficiency,metabolism Signal Transduction/physiology
Chemicals
Glial Fibrillary Acidic Protein Myelin Basic Protein Myelin Proteins Nogo Proteins Receptors, Peptide Rtn4 protein, mouse protein kinase C gamma Protein Kinase C Calcitonin Gene-Related Peptide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cafferty William B J
Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Strittmatter Stephen M
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.3827-06.2006
Published
2006-11-22
Pages
12242-50
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC2848954
Subset
IM
Grants
NINDS NIH HHS · R01 NS042304-09 · United States
NINDS NIH HHS · R37 NS033020 · United States
NINDS NIH HHS · R01 NS056485 · United States
NINDS NIH HHS · R01 NS039962-10 · United States
NINDS NIH HHS · R01 NS042304 · United States
NINDS NIH HHS · R37 NS033020-17 · United States
NINDS NIH HHS · R01 NS056485-05 · United States
NINDS NIH HHS · R01 NS039962 · United States
External Links
PubMed source DOI: 10.1523/JNEUROSCI.3827-06.2006 PMC Full Text View journal details
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