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题目:: Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes.
作者:: Prata(Diana Pinto),Breen(Gerome),Munro(Janet),Sinclair(Maggie),Osborne(Sarah),Li(Tao),Kerwin(Robert),St Clair(David),Collier(David A)
状态:: 发布时间2006-11-19 , 更新时间 2016-11-22
期刊:: Psychiatr Genet
摘要:: Although current psychiatric nosology separates bipolar disorder and schizophrenia into non-overlapping categories, there is growing evidence of a partial aetiological overlap between them from linkage, genetic epidemiology and molecular genetics studies. Thus, it is important to determine whether genes implicated in the aetiology of schizophrenia play a role in bipolar disorder, and vice versa. In this study we investigated a total of 15 single nucleotide polymorphisms (SNPs), and all possible haplotypes, of genes that have been previously implicated in schizophrenia or bipolar disorder - RGS4, PRODH, COMT and GRK3 - in a sample of 213 cases with bipolar affective disorder type 1 and 197 controls from Scotland. We analysed the polymorphisms allele-wise, genotype-wise and, for each gene, haplotype-wise but obtained no result that reached nominal significance (p<0.05) for an association with the disease status. In conclusion, we could not find evidence of association between RGS4, PRODH, COMT and GRK3 genes and bipolar affective disorder 1 in the Scottish population.
语言:: eng
DOI:

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