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PMID: 17099749 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography.

Optics letters ·Vol. 31 ·No. 23 ·2006-12-01 ·Pages 3459-61

Aguirre AD, Chen Y, Fujimoto JG, Ruvinskaya L, Devor A, Boas DA

Abstract

Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.

MeSH Terms
Animals Brain Mapping/methods Cerebral Cortex/physiology Equipment Design Equipment Failure Analysis Image Interpretation, Computer-Assisted/instrumentation,methods Microscopy, Video/instrumentation,methods Rats Tomography, Optical Coherence/instrumentation,methods
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Aguirre A D
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Chen Y
Fujimoto J G
Ruvinskaya L
Devor A
Boas D A
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Article Info
Journal
Optics letters
Abbr.
Opt Lett
ISSN
0146-9592
DOI
10.1364/ol.31.003459
Published
2006-12-01
Pages
3459-61
Language
English
Region
United States
NLM ID
7708433
PMCID
PMC2293976
Subset
IM
Grants
NIBIB NIH HHS · R01 EB000790-05 · United States
NIBIB NIH HHS · R01-EB00790 · United States
NCI NIH HHS · R01-CA75289-09 · United States
NCI NIH HHS · R01 CA075289 · United States
NIBIB NIH HHS · R01 EB000790 · United States
NEI NIH HHS · R01 EY011289-20 · United States
NIBIB NIH HHS · F31 EB005978-01 · United States
NEI NIH HHS · R01 EY011289 · United States
NEI NIH HHS · R01-EY011289-20 · United States
NIBIB NIH HHS · F31 EB005978 · United States
NCI NIH HHS · R01 CA075289-09 · United States
External Links
PubMed source DOI: 10.1364/ol.31.003459 PMC Full Text View journal details
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