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PMID: 1709703 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Feline immunodeficiency virus infects both CD4+ and CD8+ T lymphocytes.

Journal of virology ·Vol. 65 ·No. 6 ·1991-06-00 ·Pages 3359-64

Brown WC, Bissey L, Logan KS, Pedersen NC, Elder JH, Collisson EW

Abstract

Monoclonal populations of feline T cells, derived from a specific-pathogen-free cat and expressing either the CD4 or CD8 surface antigen, were infected in vitro with two geographically distinct isolates of feline immunodeficiency virus (FIV). Both infected T-cell subsets exhibited decreased cell viability, expressed FIV-encoded proteins, and generated reverse transcriptase activity. All clones examined retained their original surface phenotype after infection. It appears, therefore, that both CD4+ and CD8+ T cells may be productively infected by FIV in vivo.

MeSH Terms
Antibodies, Monoclonal/immunology Antigens, Differentiation, T-Lymphocyte/immunology CD4 Antigens/immunology CD4-Positive T-Lymphocytes/immunology,microbiology CD8 Antigens Cells, Cultured Feline Acquired Immunodeficiency Syndrome/immunology,pathology Fluorescent Antibody Technique Immunodeficiency Virus, Feline/enzymology,physiology,ultrastructure RNA-Directed DNA Polymerase/metabolism Retroviridae Proteins/biosynthesis Specific Pathogen-Free Organisms T-Lymphocytes, Regulatory/immunology,microbiology
Chemicals
Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD8 Antigens Retroviridae Proteins RNA-Directed DNA Polymerase
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Brown W C
Department of Veterinary Pathobiology, Texas A&M University, College Station 77843-4467.
Bissey L
Logan K S
Pedersen N C
Elder J H
Collisson E W
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.6.3359-3364.1991
Published
1991-06-00
Pages
3359-64
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC240997
Subset
IM
Grants
NIAID NIH HHS · AI 25825 · United States
NIAID NIH HHS · AI 28580 · United States
External Links
PubMed source DOI: 10.1128/JVI.65.6.3359-3364.1991 PMC Full Text View journal details
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