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PMID: 1709692 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Antiviral antibodies attenuate T-cell-mediated immunopathology following acute lymphocytic choriomeningitis virus infection.

Journal of virology ·Vol. 65 ·No. 6 ·1991-06-00 ·Pages 3001-6

Wright KE, Buchmeier MJ

Abstract

The role of antiviral antibody in resistance to acute lymphocytic choriomeningitis virus infection has been examined by passive transfer of monoclonal antibodies and intracerebral challenge infection. Protection of mice from lethal T-cell-mediated acute disease was observed following passive administration of antibodies either 1 day before or up to 2 days after infection. Viral replication was suppressed in protected mice, and the cytotoxic T-cell response to virus was also diminished. Virus was cleared from the brain and other tissues of protected mice without development of lethal immunopathology, suggesting that preexisting antibody may play a significant role in modulating potentially destructive effects of T-cell-mediated immune responses to pathogens.

MeSH Terms
Acute Disease Animals Antibodies, Monoclonal Antibodies, Viral/immunology B-Lymphocytes/immunology Epitopes Female Glycoproteins/immunology Immunity, Innate Immunization, Passive Lymphocytic Choriomeningitis/immunology Lymphocytic choriomeningitis virus/immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Neutralization Tests T-Lymphocytes/immunology
Chemicals
Antibodies, Monoclonal Antibodies, Viral Epitopes Glycoproteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wright K E
Department of Neuropharmacology, Research Institute of Scripps Clinic, La Jolla, California 92037.
Buchmeier M J
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34 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.65.6.3001-3006.1991
Published
1991-06-00
Pages
3001-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC240949
Subset
IM
Grants
NIAID NIH HHS · AI 16102 · United States
External Links
PubMed source DOI: 10.1128/JVI.65.6.3001-3006.1991 PMC Full Text View journal details
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