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题目:: The association between local atherosclerosis and prostate cancer.
作者:: Hager(Martina),Mikuz(Gregor),Bartsch(Georg),Kolbitsch(Christian),Moser(Patrizia L)
状态:: 发布时间2007-01-23 , 更新时间 2007-01-23
期刊:: BJU Int
摘要:: To morphometrically compare local atherosclerotic changes in cancerous prostate with those in noncancerous prostate specimens, as epidemiological studies report a positive association between the prevalence of general atherosclerosis and prostate cancer.,The intima-to-media-ratio (IMR) of 538 prostate capsular tissue arteries was measured in 50 prostate cancer-positive and 29 prostate cancer-negative specimens (including 26 with benign prostatic hyperplasia and three with normal prostatic tissue).,An IMR of >1 was significantly associated with prostate cancer and a greater risk of prostate cancer (odds ratio 2.28). The IMR was >1 in cancer-positive specimens about twice as often as in cancer-negative tissue.,Local atherosclerosis (measured by the IMR) was more pronounced in prostate cancer-positive than in prostate cancer-negative specimens. The results support the view that men with local atherosclerotic lesions are at higher risk of prostate cancer.
语言:: eng
DOI:: 10.1111/j.1464-410X.2006.06549.x

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