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PMID: 17081964 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Dynamic helix interactions in transmembrane signaling.

Cell ·Vol. 127 ·No. 3 ·2006-11-03 ·Pages 447-50

Matthews EE, Zoonens M, Engelman DM

Abstract

Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and reflect on what has been learned from these examples. Such efforts suggest that some of the most interesting properties of transmembrane helix interactions may be the least amenable to study by current techniques.

MeSH Terms

Cell Membrane/chemistry,genetics Lipid Bilayers/chemistry Membrane Lipids/metabolism Membrane Proteins/chemistry,genetics,metabolism Micelles Models, Molecular Models, Structural Mutation Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Protein-Tyrosine Kinases/metabolism Receptors, Cell Surface/genetics,metabolism Signal Transduction

Chemicals

Lipid Bilayers Membrane Lipids Membrane Proteins Micelles Receptors, Cell Surface Protein-Tyrosine Kinases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Matthews Erin E

Department of Chemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520, USA.

Zoonens Manuela

Engelman Donald M

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2006.10.016

Published

2006-11-03

Pages

447-50

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/j.cell.2006.10.016 View journal details

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