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PMID: 170681 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Thermal transitions in human plasma low density lipoproteins.

Science (New York, N.Y.) ·Vol. 190 ·No. 4212 ·1975-10-24 ·Pages 392-4

Deckelbaum RJ, Shipley GG, Small DM, Lees RS, George PK

Abstract

Thermal analysis of human plasma low density lipoproteins reveals a broad reversible transition encompassing body temperature. The calorimetric and x-ray scattering data identify this transition as a cooperation, liquid-crystalline to liquid phase change involving the cholesterol esters in the lipoprotein. This behavior requires the presence of a region rich in cholesterol ester within the lipoprotein.

MeSH Terms

Chemical Phenomena Chemistry, Physical Cholesterol/analysis Cholesterol Esters/analysis Humans Lipoproteins, VLDL/analysis,blood Phospholipids/analysis Structure-Activity Relationship Temperature Thermodynamics Triglycerides/analysis

Chemicals

Cholesterol Esters Lipoproteins, VLDL Phospholipids Triglycerides Cholesterol

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Deckelbaum R J

Shipley G G

Small D M

Lees R S

George P K

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.170681

Published

1975-10-24

Pages

392-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.170681 View journal details

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