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PMID: 1701851 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.

Nature ·Vol. 348 ·No. 6303 ·1990-00-00 ·Pages 699-704

Basset P, Bellocq JP, Wolf C, Stoll I, Hutin P, Limacher JM, Podhajcer OL, Chenard MP, Rio MC, Chambon P

Abstract

A gene has been identified that is expressed specifically in stromal cells surrounding invasive breast carcinomas. On the basis of its sequence, the product of this gene, named stromelysin-3, is a new member of the family of metalloproteinase enzymes which degrade the extracellular matrix. The suggestion is that stromelysin-3 is one of the stroma-derived factors that have long been postulated to play an important part in progression of epithelial malignancies.

MeSH Terms
Amino Acid Sequence Base Sequence Breast Neoplasms/enzymology,genetics Cloning, Molecular DNA/genetics Embryo, Mammalian/metabolism Extracellular Matrix/enzymology Female Fibroblasts/metabolism Gene Expression Growth Substances/pharmacology Humans Matrix Metalloproteinase 11 Metalloendopeptidases/genetics Molecular Sequence Data Nucleic Acid Hybridization RNA/analysis Tetradecanoylphorbol Acetate/pharmacology
Chemicals
Growth Substances RNA DNA Matrix Metalloproteinase 11 Metalloendopeptidases Tetradecanoylphorbol Acetate
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Basset P
Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Strasbourg, France.
Bellocq J P
Wolf C
Stoll I
Hutin P
Limacher J M
Podhajcer O L
Chenard M P
Rio M C
Chambon P
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/348699a0
Published
1990-00-00
Pages
699-704
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
X57766
External Links
PubMed source DOI: 10.1038/348699a0 View journal details
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