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PMID: 17016518 Published · ppublish English Editorial

Global systems biology, personalized medicine and molecular epidemiology.

Molecular systems biology ·Vol. 2 ·2006-00-00 ·Pages 52

Nicholson JK

Abstract

暂无摘要

MeSH Terms
Developed Countries Developing Countries Genotype Humans Individuality Metabolism/genetics Molecular Epidemiology/trends Personal Health Services/trends Phenotype Population Groups Systems Biology/trends
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Nicholson Jeremy K
References (27)
27 references, click to expand
  1. Assessment of analytical reproducibility of 1H NMR spectroscopy based metabonomics for large-scale epidemiological research: the INTERMAP Study.
    Anal Chem. 2006 Apr 1;78(7):2199-208 PMID: 16579598
  2. Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice.
    J Proteome Res. 2006 Feb;5(2):378-84 PMID: 16457604
  3. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?
    Diabetologia. 2006 Sep;49(9):2105-8 PMID: 16816951
  4. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice.
    Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12511-6 PMID: 16895997
  5. Transgenomic metabolic interactions in a mouse disease model: interactions of Trichinella spiralis infection with dietary Lactobacillus paracasei supplementation.
    J Proteome Res. 2006 Sep;5(9):2185-93 PMID: 16944930
  6. Statistically integrated metabonomic-proteomic studies on a human prostate cancer xenograft model in mice.
    J Proteome Res. 2006 Oct;5(10):2642-55 PMID: 17022635
  7. Pharmaco-metabonomic phenotyping and personalized drug treatment.
    Nature. 2006 Apr 20;440(7087):1073-7 PMID: 16625200
  8. 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data.
    Xenobiotica. 1999 Nov;29(11):1181-9 PMID: 10598751
  9. Infectious history.
    Science. 2000 Apr 14;288(5464):287-93 PMID: 10777411
  10. An NMR-based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse.
    FEBS Lett. 2000 Nov 10;484(3):169-74 PMID: 11078872
  11. A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations.
    Nat Biotechnol. 2001 Jan;19(1):45-50 PMID: 11135551
  12. CYP3A genetics in drug metabolism.
    Nat Med. 2001 Mar;7(3):285-7 PMID: 11231620
  13. Pharmacogenomics, ethnicity, and susceptibility genes.
    Pharmacogenomics J. 2001;1(1):19-22 PMID: 11913722
  14. Metabonomics: a platform for studying drug toxicity and gene function.
    Nat Rev Drug Discov. 2002 Feb;1(2):153-61 PMID: 12120097
  15. Drug metabolism and individualized medicine.
    Curr Drug Metab. 2003 Feb;4(1):33-44 PMID: 12570744
  16. The application of molecular genetic approaches to the study of human evolution.
    Nat Genet. 2003 Mar;33 Suppl:266-75 PMID: 12610536
  17. Opinion: understanding 'global' systems biology: metabonomics and the continuum of metabolism.
    Nat Rev Drug Discov. 2003 Aug;2(8):668-76 PMID: 12904817
  18. Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements.
    Am J Pharmacogenomics. 2003;3(6):361-70 PMID: 14672516
  19. Ethyl glucoside in human urine following dietary exposure: detection by 1H NMR spectroscopy as a result of metabonomic screening of humans.
    Analyst. 2004 Mar;129(3):259-64 PMID: 14978530
  20. Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification.
    Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12676-81 PMID: 15314235
  21. The challenges of modeling mammalian biocomplexity.
    Nat Biotechnol. 2004 Oct;22(10):1268-74 PMID: 15470467
  22. Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity.
    Pharmacogenetics. 1995 Oct;5(5):259-74 PMID: 8563766
  23. Molecular mechanisms of genetic polymorphisms of drug metabolism.
    Annu Rev Pharmacol Toxicol. 1997;37:269-96 PMID: 9131254
  24. High resolution "ultra performance" liquid chromatography coupled to oa-TOF mass spectrometry as a tool for differential metabolic pathway profiling in functional genomic studies.
    J Proteome Res. 2005 Mar-Apr;4(2):591-8 PMID: 15822939
  25. Gut microorganisms, mammalian metabolism and personalized health care.
    Nat Rev Microbiol. 2005 May;3(5):431-8 PMID: 15821725
  26. Variation in gut microbiota strongly influences individual rodent phenotypes.
    Toxicol Sci. 2005 Sep;87(1):1-2 PMID: 16158497
  27. UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation.
    Rapid Commun Mass Spectrom. 2006;20(13):1989-94 PMID: 16755610
Article Info
Journal
Molecular systems biology
Abbr.
Mol Syst Biol
ISSN
1744-4292
DOI
10.1038/msb4100095
Published
2006-00-00
Epub
2006-00-03
Pages
52
Language
English
Region
England
NLM ID
101235389
PMCID
PMC1682018
Subset
IM
External Links
PubMed source DOI: 10.1038/msb4100095 PMC Full Text View journal details
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