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PMID: 1701358 Published · ppublish English Journal Article Review

Pain and neurotransmitters.

Cellular and molecular neurobiology ·Vol. 10 ·No. 3 ·1990-09-00 ·Pages 293-302

Otsuka M, Yanagisawa M

Abstract

1. To study physiological roles of substance P (SP), gamma-aminobutyric acid (GABA), enkephalins and other endogenous substances, we developed several kinds of isolated spinal cord preparations of newborn rats. 2. In these preparations, various slow responses of spinal neurons evoked by stimulation of primary afferent C fibers were depressed by a tachykinin antagonist, spantide. These results together with many other lines of evidence suggest that SP and neurokinin A serve as pain transmitters in a subpopulation of primary afferent C fibers. 3. Some C-fiber responses in various isolated spinal cord preparations were depressed by GABA, muscimol, and opioid peptides. In contrast, bicuculline (GABA antagonist) and naloxone (opioid antagonist) potentiated the "tail pinch potential," i.e., a nociceptive response of the ventral root evoked by pinch stimulation of the tail in isolated spinal cord-tail preparation of the newborn rat. The latter results support the hypothesis that some primary afferents activate inhibitory spinal interneurons which release GABA and enkephalins as transmitters to modulate pain inputs.

MeSH Terms
Action Potentials/drug effects Afferent Pathways/drug effects,physiopathology Analgesics/pharmacology Animals Animals, Newborn Enkephalins/pharmacology,physiology GABA Antagonists Mice Neurotransmitter Agents/antagonists & inhibitors,pharmacology,physiology Nociceptors/drug effects,physiology Pain/physiopathology Rats Spinal Cord/drug effects,physiopathology Substance P/analogs & derivatives,pharmacology,physiology gamma-Aminobutyric Acid/physiology
Chemicals
Analgesics Enkephalins GABA Antagonists Neurotransmitter Agents Substance P gamma-Aminobutyric Acid spantide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Otsuka M
Department of Pharmacology, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Yanagisawa M
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39 references, click to expand
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Article Info
Journal
Cellular and molecular neurobiology
Abbr.
Cell Mol Neurobiol
ISSN
0272-4340
DOI
10.1007/BF00711176
Published
1990-09-00
Pages
293-302
Language
English
Region
United States
NLM ID
8200709
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00711176 View journal details
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