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PMID: 16983079 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Epistasis correlates to genomic complexity.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 103 ·No. 39 ·2006-09-26 ·Pages 14402-5

Sanjuán R, Elena SF

Abstract

Whether systematic genetic interactions (epistasis) occur at the genomic scale remains a challenging topic in evolutionary biology. Epistasis should make a significant contribution to variation in complex traits and influence the evolution of genetic systems as sex, diploidy, dominance, or the contamination of genomes with deleterious mutations. We have collected data from widely different organisms and quantified epistasis in a common, per-generation scale. Simpler genomes, such as those of RNA viruses, display antagonistic epistasis (mutations have smaller effects together than expected); bacterial microorganisms do not apparently deviate from independent effects, whereas in multicellular eukaryotes, a transition toward synergistic epistasis occurs (mutations have larger effects together than expected). We propose that antagonistic epistasis might be a property of compact genomes with few nonpleiotropic biological functions, whereas in complex genomes, synergism might emerge from mutational robustness.

MeSH Terms
Animals Aspergillus/genetics Drosophila melanogaster/genetics Epistasis, Genetic Escherichia coli/genetics Genome/genetics Genome, Bacterial/genetics Genome, Fungal/genetics Genome, Insect/genetics Genome, Viral/genetics Meta-Analysis as Topic Saccharomyces cerevisiae/genetics Vesicular stomatitis Indiana virus/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sanjuán Rafael
Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-UPV, 46022 València, Spain. rafsaver@ibmcp.upv.es
Elena Santiago F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.0604543103
Email
rafsaver@ibmcp.upv.es
Published
2006-09-26
Epub
2006-00-18
Pages
14402-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1599975
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0604543103 PMC Full Text View journal details
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