Expression of granulysin in polymyositis and inclusion-body myositis.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 77 ·No. 10 ·2006-10-00 ·Pages 1187-90

Ikezoe K, Ohshima S, Osoegawa M, Tanaka M, Ogawa K, Nagata K, Kira JI

Abstract

Granulysin, a recently defined cytolytic molecule, is expressed in cytotoxic T cells and natural killer cells in a similar way to perforin, which is reported to have a major role in the pathogenesis of polymyositis and inclusion-body myositis (IBM). To clarify the role of granulysin in polymyositis and IBM. The expression of granulysin and perforin was examined by double staining with CD8, CD4 and CD56 in endomysial infiltrating cells and autoinvasive cells in muscle biopsy specimens of 17 patients with polymyositis (6 steroid resistant and 11 steroid responsive) and of 7 patients with IBM. Similar to perforin, granulysin was expressed in CD8, CD4 or CD56 cells in patients with polymyositis and IBM. The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis.

MeSH Terms

Antigens, Differentiation, T-Lymphocyte/metabolism Biopsy CD4 Antigens CD4-Positive T-Lymphocytes/metabolism CD56 Antigen CD8 Antigens CD8-Positive T-Lymphocytes/metabolism Drug Resistance Female Gene Expression Profiling Humans Immunohistochemistry Male Muscle, Skeletal/metabolism Myositis, Inclusion Body/drug therapy,metabolism Polymyositis/drug therapy,metabolism Steroids/pharmacology

Chemicals

Antigens, Differentiation, T-Lymphocyte CD4 Antigens CD56 Antigen CD8 Antigens GNLY protein, human Steroids

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Ikezoe K

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Ohshima S

Osoegawa M

Tanaka M

Ogawa K

Nagata K

Kira J-i

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21 references, click to expand

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Article Info

Journal

Journal of neurology, neurosurgery, and psychiatry

Abbr.

J Neurol Neurosurg Psychiatry

ISSN

1468-330X

DOI

10.1136/jnnp.2005.081810

Published

2006-10-00

Pages

1187-90

Language

English

Region

England

NLM ID

2985191R

PMCID

PMC2077550

Subset

Corrections

CommentIn

PMID: 16980654

External Links

PubMed source DOI: 10.1136/jnnp.2005.081810 PMC Full Text View journal details

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Expression of granulysin in polymyositis and inclusion-body myositis.

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