Abstract
Heterotopic heart and orthotopic liver grafts from ACI donors were transplanted to Lewis rat recipients that were treated with a 3 (or 4) day course of FK506 IM that was started on postoperative day 0, 2, 3, 4, 5, or 6. Hearts, which rejected after a median of 6 days in untreated controls, always had prolonged survival (median 91 days) when treatment was started on postoperative day 4. The results were inferior when treatment was started earlier or later than this, but even when the first dose of FK506 was on postoperative day 5, one day before rejection was imminent in controls, the median survival was 50 days. The poorest results with a median graft survival of only 36 days were obtained when injections were on days 0-3. Results were similar with liver grafts that rejected after a median time of 10 days in nontreated controls but that usually survived permanently after a 3 (or 4) day FK506 course starting on day 0, 2, 3, or 4. Therapy started on day 6 was too late.
MeSH Terms
Animals
Anti-Bacterial Agents/administration & dosage
Drug Administration Schedule
Graft Rejection/drug effects
Graft Survival/drug effects
Heart Transplantation/immunology,pathology
Immunosuppressive Agents
Liver Transplantation/immunology,pathology
Rats
Rats, Inbred Strains
Tacrolimus
Chemicals
Anti-Bacterial Agents
Immunosuppressive Agents
Tacrolimus
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Murase N
Department of Surgery, University of Pittsburgh, Pennsylvania.
Kim D G
Todo S
Cramer D V
Fung J J
Starzl T E
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