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PMID: 16956919 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications.

Gut ·Vol. 56 ·No. 2 ·2007-02-00 ·Pages 293-303

Mudter J, Neurath MF

Abstract

暂无摘要

MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Apoptosis/immunology Azathioprine/therapeutic use Cell Survival/immunology Crohn Disease/etiology,immunology,therapy Humans Immunity, Mucosal/immunology Immunosuppressive Agents/therapeutic use Inflammatory Bowel Diseases/drug therapy,immunology Interleukin-12/immunology Interleukin-6/immunology Intestinal Mucosa/immunology Mesalamine/therapeutic use Signal Transduction/immunology T-Lymphocytes/drug effects,immunology Tumor Necrosis Factor-alpha/immunology
Chemicals
Anti-Inflammatory Agents, Non-Steroidal Immunosuppressive Agents Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-12 Mesalamine Azathioprine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mudter J
Laboratory of Immunology, First Medical Clinic, University of Mainz, 55131 Mainz, Germany. mudter@uni-mainz.de
Neurath M F
References (94)
94 references, click to expand
  1. Induction of T lymphocyte apoptosis by sulphasalazine in patients with Crohn's disease.
    Gut. 2004 Nov;53(11):1632-8 PMID: 15479684
  2. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.
    J Biol Chem. 2003 Mar 14;278(11):8869-72 PMID: 12527755
  3. Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis.
    Gastroenterology. 1999 Mar;116(3):557-65 PMID: 10029614
  4. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.
    Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84 PMID: 12571365
  5. Death receptor signaling and its function in the immune system.
    Curr Dir Autoimmun. 2006;9:1-17 PMID: 16394652
  6. p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling.
    J Clin Invest. 2002 Jun;109(11):1481-92 PMID: 12045262
  7. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial.
    Lancet. 2002 May 4;359(9317):1541-9 PMID: 12047962
  8. Apoptosis and gastrointestinal tract.
    Ital J Gastroenterol Hepatol. 1999 Mar;31(2):162-72 PMID: 10363202
  9. Biologic therapy for inflammatory bowel disease.
    Drugs. 2005;65(16):2253-86 PMID: 16266194
  10. Dna in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments.
    FEBS Lett. 1976 Dec 31;72(2):271-4 PMID: 16386038
  11. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)
    Clin Exp Immunol. 1995 Dec;102(3):448-55 PMID: 8536356
  12. Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis.
    J Clin Invest. 1996 Dec 1;98(11):2616-22 PMID: 8958226
  13. Interleukin-12 antagonists as new therapeutic agents in inflammatory bowel disease.
    Pathobiology. 2002-2003;70(3):177-83 PMID: 12571423
  14. IL-12 decreases activation-induced cell death in human naive Th cells costimulated by intercellular adhesion molecule-1. I. IL-12 alters caspase processing and inhibits enzyme function.
    J Immunol. 2001 Jul 15;167(2):749-58 PMID: 11441079
  15. Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease.
    J Gastroenterol Hepatol. 1999 Oct;14(10):987-96 PMID: 10530495
  16. Commensal bacteria as targets in Crohn's disease.
    Gastroenterology. 2000 Jul;119(1):254-7 PMID: 10889177
  17. Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept.
    Aliment Pharmacol Ther. 2005 Feb 1;21(3):251-8 PMID: 15691299
  18. Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease.
    J Immunol. 2005 Aug 15;175(4):2293-300 PMID: 16081798
  19. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?
    Nat Med. 1996 Dec;2(12):1361-6 PMID: 8946836
  20. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.
    Immunity. 1999 Dec;11(6):709-19 PMID: 10626893
  21. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial.
    Gastroenterology. 2006 Feb;130(2):323-33; quiz 591 PMID: 16472588
  22. IL-6 is required for the development of Th1 cell-mediated murine colitis.
    J Immunol. 2000 May 1;164(9):4878-82 PMID: 10779797
  23. Death and anti-death: tumour resistance to apoptosis.
    Nat Rev Cancer. 2002 Apr;2(4):277-88 PMID: 12001989
  24. Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells.
    Gastroenterology. 2002 May;122(5):1334-45 PMID: 11984520
  25. C-reactive protein: a physiological activator of interleukin 6 receptor shedding.
    J Exp Med. 1999 Feb 1;189(3):599-604 PMID: 9927522
  26. Crohn's disease.
    Lancet. 2002 Jan 5;359(9300):62-9 PMID: 11809204
  27. Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis.
    Gut. 2004 Nov;53(11):1624-31 PMID: 15479683
  28. Basic aspects of development and maturation of the brain: embryological contributions to neuroendocrinology.
    Psychoneuroendocrinology. 1983;8(2):157-81 PMID: 6353468
  29. Mechanisms of action of mycophenolate mofetil.
    Lupus. 2005;14 Suppl 1:s2-8 PMID: 15803924
  30. Crohn's disease: a defensin deficiency syndrome?
    Eur J Gastroenterol Hepatol. 2003 Jun;15(6):627-34 PMID: 12840673
  31. Signaling for death of lymphoid cells.
    Curr Opin Immunol. 1993 Jun;5(3):368-73 PMID: 7688515
  32. Mucosal T cells: mediators or guardians of inflammatory bowel disease?
    Curr Opin Gastroenterol. 2003 Jul;19(4):343-9 PMID: 15703575
  33. Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases.
    Am J Gastroenterol. 2005 Jan;100(1):64-72 PMID: 15654782
  34. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.
    Gastroenterology. 1999 Nov;117(5):1078-88 PMID: 10535870
  35. Cell death: critical control points.
    Cell. 2004 Jan 23;116(2):205-19 PMID: 14744432
  36. Apoptosis in the development and maintenance of the immune system.
    Nat Immunol. 2003 May;4(5):410-5 PMID: 12719730
  37. Two CD95 (APO-1/Fas) signaling pathways.
    EMBO J. 1998 Mar 16;17(6):1675-87 PMID: 9501089
  38. JunD mediates survival signaling by the JNK signal transduction pathway.
    Mol Cell. 2003 Jun;11(6):1479-89 PMID: 12820962
  39. Apoptosis in neural development and disease.
    Annu Rev Neurosci. 2000;23:73-87 PMID: 10845059
  40. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.
    Nature. 2001 May 31;411(6837):603-6 PMID: 11385577
  41. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
    Nat Med. 2000 May;6(5):583-8 PMID: 10802717
  42. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.
    J Clin Invest. 2003 Apr;111(8):1133-45 PMID: 12697733
  43. Transmembrane TNF-alpha, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease.
    Gastroenterology. 2001 Nov;121(5):1242-6 PMID: 11677219
  44. Live or let die: the cell's response to p53.
    Nat Rev Cancer. 2002 Aug;2(8):594-604 PMID: 12154352
  45. Defective mucosal T cell death is sustainably reverted by infliximab in a caspase dependent pathway in Crohn's disease.
    Gut. 2004 Jan;53(1):70-7 PMID: 14684579
  46. The soluble interleukin-6 receptor is generated by shedding.
    Eur J Immunol. 1993 Feb;23(2):473-80 PMID: 8436181
  47. Tumor necrosis factor: an apoptosis JuNKie?
    Cell. 2004 Feb 20;116(4):491-7 PMID: 14980217
  48. IL-6 and Crohn's disease.
    Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):125-30 PMID: 14561164
  49. Extinction of IL-12 signaling promotes Fas-mediated apoptosis of antigen-specific T cells.
    J Immunol. 1999 Jun 15;162(12):7233-40 PMID: 10358170
  50. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
    Cell. 1998 Aug 21;94(4):491-501 PMID: 9727492
  51. Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway.
    Gastroenterology. 2001 Nov;121(5):1145-57 PMID: 11677207
  52. Mechanisms of disease: defensins in gastrointestinal diseases.
    Nat Clin Pract Gastroenterol Hepatol. 2005 Sep;2(9):406-15 PMID: 16265431
  53. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease.
    Gastroenterology. 2003 Jun;124(7):1774-85 PMID: 12806611
  54. A unique role for IL-23 in promoting cellular immunity.
    J Leukoc Biol. 2003 Jan;73(1):49-56 PMID: 12525561
  55. Apoptosis and T-cell repertoire selection in the thymus.
    Ann N Y Acad Sci. 1992 Nov 21;663:305-10 PMID: 1482060
  56. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes.
    Immunol Today. 1993 Jul;14(7):338-9 PMID: 8363721
  57. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.
    Gut. 2003 Jan;52(1):144-51 PMID: 12477778
  58. Death in embryonic systems.
    Science. 1966 Nov 4;154(3749):604-12 PMID: 5332319
  59. Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation.
    Inflamm Bowel Dis. 2005 Feb;11(2):91-8 PMID: 15677901
  60. An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo.
    Gut. 2004 Mar;53(3):339-45 PMID: 14960512
  61. Death and T cells.
    Immunol Rev. 1993 Jun;133:119-29 PMID: 7901146
  62. Infliximab induced T lymphocyte apoptosis in Crohn's disease.
    J Rheumatol Suppl. 2005 Mar;74:26-30 PMID: 15742461
  63. Apoptosis: a different type of cell death.
    FASEB J. 1992 Apr;6(7):2450-5 PMID: 1563596
  64. The pathophysiologic rationale for biological therapies in inflammatory bowel disease.
    Curr Opin Gastroenterol. 2005 Jul;21(4):431-7 PMID: 15930983
  65. Tumor necrosis factor-receptor 2 is up-regulated on lamina propria T cells in Crohn's disease and promotes experimental colitis in vivo.
    Eur J Immunol. 2002 Nov;32(11):3142-51 PMID: 12555659
  66. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations.
    Lancet. 2001 Jun 16;357(9272):1925-8 PMID: 11425413
  67. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
    J Exp Med. 1995 May 1;181(5):1755-62 PMID: 7722452
  68. Lessons to be learned from the NOD2 gene in Crohn's disease.
    Eur J Gastroenterol Hepatol. 2003 Jun;15(6):593-7 PMID: 12840668
  69. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis.
    Pathobiology. 2002-2003;70(3):170-6 PMID: 12571422
  70. Polymorphisms in apoptosis genes predict response to infliximab therapy in luminal and fistulizing Crohn's disease.
    Aliment Pharmacol Ther. 2005 Oct 1;22(7):613-26 PMID: 16181301
  71. Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis.
    Gastroenterology. 2005 Jul;129(1):185-203 PMID: 16012947
  72. A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease.
    Gastroenterology. 2005 Sep;129(3):807-18 PMID: 16143120
  73. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.
    Immunity. 1999 Jan;10(1):39-49 PMID: 10023769
  74. Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease.
    J Gastroenterol. 2002 Nov;37 Suppl 14:56-61 PMID: 12572867
  75. T-lymphocyte death during shutdown of an immune response.
    Trends Immunol. 2004 Nov;25(11):610-5 PMID: 15489190
  76. Apoptosis signaling in lymphocytes.
    Curr Opin Immunol. 1999 Jun;11(3):277-85 PMID: 10375553
  77. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
    Nature. 2001 May 31;411(6837):599-603 PMID: 11385576
  78. Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.
    Int Immunol. 2006 Apr;18(4):555-63 PMID: 16540526
  79. Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.
    Trends Immunol. 2001 Jan;22(1):21-6 PMID: 11286687
  80. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor.
    Cell. 1995 Dec 1;83(5):793-802 PMID: 8521496
  81. Tumor necrosis factor signaling.
    Cell Death Differ. 2003 Jan;10(1):45-65 PMID: 12655295
  82. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice.
    Nat Med. 1996 Sep;2(9):998-1004 PMID: 8782457
  83. Mechanisms of infliximab: the reverse side of a drug effect.
    Inflamm Bowel Dis. 2004 Feb;10 Suppl 1:S38-43 PMID: 15168830
  84. Anti-interleukin-12 antibody for active Crohn's disease.
    N Engl J Med. 2004 Nov 11;351(20):2069-79 PMID: 15537905
  85. Resistance of Crohn's disease T cells to multiple apoptotic signals is associated with a Bcl-2/Bax mucosal imbalance.
    J Immunol. 1999 Jul 15;163(2):1081-90 PMID: 10395708
  86. IL-6 transsignaling: the in vivo consequences.
    J Interferon Cytokine Res. 2005 May;25(5):241-53 PMID: 15871661
  87. Programmed cell death in animal development.
    Cell. 1997 Feb 7;88(3):347-54 PMID: 9039261
  88. A histochemical study of hypertrophy and ischaemic injury of rat liver with special reference to changes in lysosomes.
    J Pathol Bacteriol. 1965 Oct;90(2):419-35 PMID: 5849603
  89. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).
    J Exp Med. 2000 Jun 19;191(12):2053-64 PMID: 10859330
  90. Shrinkage necrosis: a distinct mode of cellular death.
    J Pathol. 1971 Sep;105(1):13-20 PMID: 4108566
  91. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics.
    Gastroenterology. 2004 May;126(6):1620-33 PMID: 15168372
  92. Alterations of the CARD15/NOD2 gene and the impact on management and treatment of Crohn's disease patients.
    Dig Dis. 2003;21(4):339-45 PMID: 14752224
  93. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease.
    Gut. 2002 Feb;50(2):206-11 PMID: 11788561
  94. Treatment of Crohn's disease with anti-IL-6 receptor antibody.
    J Gastroenterol. 2005 Mar;40 Suppl 16:32-4 PMID: 15902961
Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.2005.090464
Email
mudter@uni-mainz.de
Published
2007-02-00
Epub
2006-00-06
Pages
293-303
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1856765
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.2005.090464 PMC Full Text View journal details
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