Tissue distribution of HRF20, a novel factor preventing the membrane attack of homologous complement, and its predominant expression on endothelial cells in vivo.

Immunology ·Vol. 70 ·No. 2 ·1990-06-00 ·Pages 145-9

Nose M, Katoh M, Okada N, Kyogoku M, Okada H

Abstract

A 20,000 molecular weight (MW) homologous restriction factor (HRF20), detected by 1F5 monoclonal antibody (mAb), is present on blood cell surfaces and inhibits the terminal stage of the formation of membrane attack complexes by homologous complement activation. The tissue distribution of HRF20 was studied by immunohistochemical analysis using 1F5. HRF20 was predominantly expressed on endothelial cells of systemic arteries, veins and capillaries, as well as on the surface of cultured human umbilical vein endothelial cells. HRF20 was also detected, to a lesser extent, on the Schwann sheath of peripheral nerve fibres, ependymal cells and certain epithelial cells such as acinar cells of the salivary gland, bronchial epithelium, renal tubules and squamous epithelium. The distribution pattern of HRF20 differed somewhat from that of decay-accelerating factor (DAF), which is another membrane inhibitor of homologous complement activation.

MeSH Terms

Antibodies, Monoclonal Antigens, Differentiation/analysis CD59 Antigens Cells, Cultured Complement Membrane Attack Complex/biosynthesis Endothelium/analysis Endothelium, Vascular/analysis Epithelium/analysis Humans Immunoenzyme Techniques Membrane Glycoproteins/analysis Nervous System/analysis

Chemicals

Antibodies, Monoclonal Antigens, Differentiation CD59 Antigens Complement Membrane Attack Complex Membrane Glycoproteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Nose M

Department of Pathology, Tohoku University School of Medicine, Sendai, Japan.

Katoh M

Okada N

Kyogoku M

Okada H

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Article Info

Journal

Immunology

Abbr.

Immunology

ISSN

0019-2805

Published

1990-06-00

Pages

145-9

Language

English

Region

England

NLM ID

0374672

PMCID

PMC1384184

Subset

External Links

PubMed source PMC Full Text View journal details

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Tissue distribution of HRF20, a novel factor preventing the membrane attack of homologous complement, and its predominant expression on endothelial cells in vivo.

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