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PMID: 1695228 Published · ppublish English Journal Article

Nucleolar organiser regions: new prognostic variable in breast carcinomas.

Journal of clinical pathology ·Vol. 43 ·No. 5 ·1990-05-00 ·Pages 390-2

Sivridis E, Sims B

Abstract

Nucleolar organiser regions (NORs), which are important for regulating protein synthesis, were identified in 20 breast carcinomas by means of a silver (Ag) staining technique. Infiltrating neoplasms with metastases in four or more axillary lymph nodes possessed, on average, a greater number of AgNORs per cell nucleus compared with neoplasms without nodal disease, or with one to three positive lymph nodes. The size, morphology, and distribution of AgNORs within the nucleus were also different in the two study groups. Overall, these findings suggest that breast carcinomas with multiple, irregular, and widely dispersed AgNORs tend to be of high grade malignancy.

MeSH Terms
Breast Neoplasms/pathology Female Humans Lymphatic Metastasis Neoplasm Invasiveness Nucleolus Organizer Region/pathology Prognosis Staining and Labeling
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sivridis E
Department of Histopathology, General Hospital, Alexandroupolis, Greece.
Sims B
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31 references, click to expand
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.43.5.390
Published
1990-05-00
Pages
390-2
Language
English
Region
England
NLM ID
0376601
PMCID
PMC502439
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.43.5.390 PMC Full Text View journal details
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