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PMID: 16951082 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

History and structure of sub-Saharan populations of Drosophila melanogaster.

Genetics ·Vol. 174 ·No. 2 ·2006-10-00 ·Pages 915-29

Pool JE, Aquadro CF

Abstract

Drosophila melanogaster is an important model organism in evolutionary genetics, yet little is known about the population structure and the demographic history of this species within sub-Saharan Africa, which is thought to contain its ancestral range. We surveyed nucleotide variation at four 1-kb fragments in 240 individual lines representing 21 sub-Saharan and 4 Palearctic population samples of D. melanogaster. In agreement with recent studies, we find a small but significant level of genetic differentiation within sub-Saharan Africa. A clear geographic pattern is observed, with eastern and western African populations composing two genetically distinct groups. This pattern may have resulted from a relatively recent establishment of D. melanogaster in western Africa. Eastern populations show greater evidence for long-term stability, consistent with the hypothesis that eastern Africa contains the ancestral range of the species. Three sub-Saharan populations show evidence for cosmopolitan introgression. Apart from those cases, the closest relationships between Palearctic and sub-Saharan populations involve a sample from the rift zone (Uganda), suggesting that the progenitors of Palearctic D. melanogaster might have come from this region. Finally, we find a large excess of singleton polymorphisms in the full data set, which is best explained by a combination of population growth and purifying selection.

MeSH Terms
Africa South of the Sahara Animals Biological Evolution Drosophila melanogaster/classification,genetics Female Genetic Variation Genetics, Population Molecular Sequence Data Natural History
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pool John E
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA. jep36@cornell.edu
Aquadro Charles F
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.106.058693
Email
jep36@cornell.edu
Published
2006-10-00
Epub
2006-00-01
Pages
915-29
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1602083
Subset
IM
Grants
NIGMS NIH HHS · R01 GM036431 · United States
NIGMS NIH HHS · GM36431 · United States
Databases
GENBANK
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PubMed source DOI: 10.1534/genetics.106.058693 PMC Full Text View journal details
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