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PMID: 1694043 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Identification of an inhibitor of neovascularization from cartilage.

Science (New York, N.Y.) ·Vol. 248 ·No. 4961 ·1990-06-15 ·Pages 1408-10

Moses MA, Sudhalter J, Langer R

Abstract

Certain tissues such as cartilage are resistant to vascular invasion, yet no single tissue-derived molecule that can inhibit angiogenesis has been reported. A protein derived from cartilage was purified that inhibits angiogenesis in vivo and capillary endothelial cell proliferation and migration in vitro in three separate bioassays. This protein is also an inhibitor of mammalian collagenase. These findings may help elucidate the mechanisms by which neovascularization is controlled in both normal and pathological states.

MeSH Terms

Adrenal Cortex/blood supply Allantois/blood supply Amino Acid Sequence Angiogenesis Inducing Agents/antagonists & inhibitors Angiogenesis Inhibitors Animals Biological Assay Capillaries/cytology Cartilage/analysis Cattle Cell Division/drug effects Cell Movement/drug effects Chick Embryo Chorion/blood supply Endothelium, Vascular/cytology Fibroblast Growth Factors/pharmacology Growth Inhibitors Molecular Sequence Data Neovascularization, Pathologic Proteins/isolation & purification,pharmacology

Chemicals

Angiogenesis Inducing Agents Angiogenesis Inhibitors Growth Inhibitors Proteins Fibroblast Growth Factors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Moses M A

Department of Surgery, Children's Hospital Medical Center, Boston, MA 02115.

Sudhalter J

Langer R

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.1694043

Published

1990-06-15

Pages

1408-10

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NEI NIH HHS · EY05333 · United States

NEI NIH HHS · EY06047 · United States

External Links

PubMed source DOI: 10.1126/science.1694043 View journal details

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Identification of an inhibitor of neovascularization from cartilage.

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