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PMID: 16908667 Published · ppublish English Journal Article Review

Phosphoinositide signaling plays a key role in cytokinesis.

The Journal of cell biology ·Vol. 174 ·No. 4 ·2006-08-14 ·Pages 485-90

Janetopoulos C, Devreotes P

Abstract

To perform the vital functions of motility and division, cells must undergo dramatic shifts in cell polarity. Recent evidence suggests that polarized distributions of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, which are clearly important for regulating cell morphology during migration, also play an important role during the final event in cell division, which is cytokinesis. Thus, there is a critical interplay between the membrane phosphoinositides and the cytoskeletal cortex that regulates the complex series of cell shape changes that accompany these two processes.

MeSH Terms
Animals Cell Polarity/physiology Cell Shape/physiology Cytokinesis/physiology Cytoskeleton/metabolism Humans Phosphatidylinositol 4,5-Diphosphate/metabolism Phosphatidylinositol Phosphates/metabolism Phosphatidylinositols/metabolism Signal Transduction/physiology
Chemicals
Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates Phosphatidylinositols phosphatidylinositol 3,4,5-triphosphate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Janetopoulos Chris
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA.
Devreotes Peter
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200603156
Published
2006-08-14
Pages
485-90
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2064254
Subset
IM
Grants
NIGMS NIH HHS · R01 GM028007 · United States
External Links
PubMed source DOI: 10.1083/jcb.200603156 PMC Full Text View journal details
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