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PMID: 16906750 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way.

Accounts of chemical research ·Vol. 39 ·No. 8 ·2006-08-00 ·Pages 539-49

Wilson RM, Danishefsky SJ

Abstract

The possibility for the application of organic synthesis to the discovery of new agents in combating neurodegenerative disorders is described. Our focus has been on agents derived from natural-product leads and natural products themselves prepared through total synthesis. Herein, we describe some of the chemistry as well as interesting observations made along the way.

MeSH Terms
Biological Products/chemical synthesis,chemistry,therapeutic use Bridged-Ring Compounds/chemical synthesis,chemistry Dioxoles/chemical synthesis,chemistry Diterpenes/chemical synthesis,chemistry Lactones/chemical synthesis,chemistry Molecular Structure Neurodegenerative Diseases/drug therapy Sesquiterpenes/chemical synthesis,chemistry Terpenes/chemical synthesis,chemistry Triterpenes/chemical synthesis,chemistry
Chemicals
11-O-debenzoyltashironin Biological Products Bridged-Ring Compounds Dioxoles Diterpenes Lactones NGA 0187 Sesquiterpenes Terpenes Triterpenes garsubellin A jiadifenin merrilactone A scabronine G tricycloillicinone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wilson Rebecca M
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10021, USA.
Danishefsky Samuel J
Article Info
Journal
Accounts of chemical research
Abbr.
Acc Chem Res
ISSN
0001-4842
DOI
10.1021/ar068018n
Published
2006-08-00
Pages
539-49
Language
English
Region
United States
NLM ID
0157313
Subset
IM
Grants
NCI NIH HHS · CA103823 · United States
NHLBI NIH HHS · HL25848 · United States
External Links
PubMed source DOI: 10.1021/ar068018n View journal details
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