Rough sheets and smooth tubules.

Cell ·Vol. 126 ·No. 3 ·2006-08-11 ·Pages 435-9

Shibata Y, Voeltz GK, Rapoport TA

Abstract

The endoplasmic reticulum (ER) has distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER.

MeSH Terms

Animals Cytoplasmic Vesicles/metabolism,ultrastructure Endoplasmic Reticulum, Rough/metabolism,ultrastructure Endoplasmic Reticulum, Smooth/metabolism,ultrastructure Humans Intracellular Membranes/metabolism,ultrastructure Microtubules/metabolism,ultrastructure Protein Biosynthesis/physiology Protein Transport/physiology Ribosomes/genetics,metabolism Steroids/biosynthesis

Chemicals

Steroids

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Shibata Yoko

Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Voeltz Gia K

Rapoport Tom A

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2006.07.019

Published

2006-08-11

Pages

435-9

Language

English

Region

United States

NLM ID

0413066

Subset

External Links

PubMed source DOI: 10.1016/j.cell.2006.07.019 View journal details

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