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题目:: Glioblastoma cell death induced by asiatic acid.
作者:: Cho(C W),Choi(D S),Cardone(M H),Kim(C W),Sinskey(A J),Rha(C)
状态:: 发布时间2006-10-02 , 更新时间 2013-11-21
期刊:: Cell Biol Toxicol
摘要:: Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon cancer RKO cells. AA-induced glioblastoma cell death is associated with decreased mitochondrial membrane potential, activation of caspase-9 and -3, and increased intracellular free Ca2+. Although treatment of glioblastoma cells with the caspase inhibitor zVAD-fmk completely abolished AA-induced caspase activation, it did not significantly block AA-induced cell death. AA-induced cell death was significantly prevented by an intracellular Ca2+ inhibitor, BAPTA/AM. Taken together, these results indicate that AA induces cell death by both apoptosis and necrosis, with Ca2+-mediated necrotic cell death predominating.
语言:: eng
DOI:: 10.1007/s10565-006-0104-2

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