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PMID: 16886054 Published · ppublish English Comment Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Costimulation couture: a designer approach to regulating autoimmunity.

The Journal of clinical investigation ·Vol. 116 ·No. 8 ·2006-08-00 ·Pages 2080-3

Ansari MJ, Sayegh MH

Abstract

Negative or inhibitory costimulatory pathways regulate T cell activation and play a role in peripheral tolerance. Targeting these pathways harnesses the physiologic mechanisms of regulating autoimmunity and could prove beneficial for the therapy of autoimmune diseases. However, attempts at targeting these pathways have been fraught with difficulties. In this issue of the JCI, Fife et al. describe a creative approach for targeting CTL-associated antigen 4 (CTLA-4) on activated T cells via genetically engineered B cells to prevent autoimmune diabetes in the NOD mouse (see the related article beginning on page 2252). Novel "designer" strategies targeting negative costimulatory pathways provide reasons for optimism in the search for a cure for devastating autoimmune diseases.

MeSH Terms
Antigens, CD Antigens, Differentiation/immunology Autoimmune Diseases/immunology,therapy B-Lymphocytes/immunology CTLA-4 Antigen Diabetes Mellitus/immunology Humans Lymphocyte Activation Models, Immunological T-Lymphocytes/immunology
Chemicals
Antigens, CD Antigens, Differentiation CTLA-4 Antigen CTLA4 protein, human Ctla4 protein, mouse
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ansari Mohammed Javeed
Transplantation Research Center, Renal Division, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA.
Sayegh Mohamed H
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI29455
Published
2006-08-00
Pages
2080-3
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC1523390
Subset
IM
Grants
NIAID NIH HHS · P01 AI041521 · United States
NIAID NIH HHS · P01 AI056299 · United States
Corrections
CommentOn
PMID: 16886063
External Links
PubMed source DOI: 10.1172/JCI29455 PMC Full Text View journal details
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