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PMID: 16870791 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural

qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States.

Antimicrobial agents and chemotherapy ·Vol. 50 ·No. 8 ·2006-08-00 ·Pages 2872-4

Robicsek A, Strahilevitz J, Sahm DF, Jacoby GA, Hooper DC

Abstract

We screened 313 ceftazidime-resistant Enterobacteriaceae isolates obtained in the United States from 1999 to 2004 for all three known qnr genes. A qnr gene was present in 20% of Klebsiella pneumoniae isolates, 31% of Enterobacter sp. isolates, and 4% of Escherichia coli isolates. qnrA and qnrB occurred with equivalent frequencies and, except for qnrB in enterobacters, were stable over time. qnrS was absent.

MeSH Terms
Age Distribution Amino Acid Sequence Anti-Bacterial Agents/pharmacology Bacterial Proteins/genetics Ceftazidime/pharmacology Drug Resistance, Multiple, Bacterial/genetics Enterobacteriaceae/drug effects,genetics,isolation & purification Enterobacteriaceae Infections/epidemiology,microbiology Escherichia coli Female Genes, Bacterial Humans Inpatients Klebsiella pneumoniae Male Microbial Sensitivity Tests Middle Aged Molecular Sequence Data Prevalence Retrospective Studies Salmonella enterica/classification,genetics Sequence Homology, Amino Acid United States/epidemiology
Chemicals
Anti-Bacterial Agents Bacterial Proteins Ceftazidime
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Robicsek A
Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114-2696, USA.
Strahilevitz J
Sahm D F
Jacoby G A
Hooper D C
References (8)
8 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.01647-05
Published
2006-08-00
Pages
2872-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC1538681
Subset
IM
Grants
NIAID NIH HHS · R01 AI043312 · United States
NIAID NIH HHS · R01 AI057576 · United States
NIAID NIH HHS · AI43312 · United States
NIAID NIH HHS · AI57576 · United States
Databases
GENBANK
DQ303920, DQ303921
External Links
PubMed source DOI: 10.1128/AAC.01647-05 PMC Full Text View journal details
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