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PMID: 16827897 Published · ppublish English Journal Article Research Support, N.I.H., Extramural

The fate of effector CD8 T cells in vivo is controlled by the duration of antigen stimulation.

Immunology ·Vol. 118 ·No. 3 ·2006-07-00 ·Pages 361-71

Huang X, Yang Y

Abstract

What controls the fate of the T-cell response remains incompletely defined. Gain of effector function facilitated by costimulation has been thought to be a crucial factor in determining the outcome of the T-cell response, i.e. long-term memory in the presence of costimulation versus tolerance induction in the absence of costimulation. In this study, we show that while costimulation or cognate CD4 helps to promote the acquisition of effector function during the initial phase of the CD8 T-cell response, the fate of effector CD8 T cells is controlled by the duration of subsequent antigenic stimulation. Effector CD8 T cells differentiate into memory cells only after clearance of antigen, whereas in the presence of persistent antigen, effector CD8 T cells are tolerized. Furthermore, protective immunity against tumour cannot develop in the persisting antigen environment. These results suggest that removal of persisting antigen by other means might be a prerequisite for effective immunotherapy in cancer.

MeSH Terms
Adoptive Transfer Animals Antigens, Viral/administration & dosage,immunology CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology Cell Differentiation/immunology Cells, Cultured Cytotoxicity, Immunologic Hemagglutinins, Viral/immunology Immune Tolerance/immunology Immunologic Memory/immunology Lymphocyte Cooperation/immunology Lymphoma/immunology,prevention & control Mice Mice, Inbred Strains Mice, Transgenic Neoplasm Transplantation
Chemicals
Antigens, Viral Hemagglutinins, Viral
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huang Xiaopei
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Yang Yiping
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
DOI
10.1111/j.1365-2567.2006.02381.x
Published
2006-07-00
Pages
361-71
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1782300
Subset
IM
Grants
NCI NIH HHS · K22 CA093659 · United States
NCI NIH HHS · P01 CA047741 · United States
NCI NIH HHS · CA047741 · United States
NCI NIH HHS · CA093659 · United States
External Links
PubMed source DOI: 10.1111/j.1365-2567.2006.02381.x PMC Full Text View journal details
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