| GeneLibs

题目:: TAOS1, a novel marker for advanced esophageal squamous cell carcinoma.
作者:: Komatsu(Yoshinao),Hibi(Kenji),Kodera(Yasuhiro),Akiyama(Seiji),Ito(Katsuki),Nakao(Akimasa)
状态:: 发布时间2006-07-07 , 更新时间 2015-11-19
期刊:: Anticancer Res
摘要:: TAOS1 (tumor amplified and overexpressed sequence 1) was recently cloned and found to be possibly important in driving the amplification of 11q13 in oral squamous cell carcinoma (SCC).,Quantitative RT-PCR was performed to determine the possible relationship between TAOS1 gene expression levels and clinicopathological features in esophageal SCC.,TAOS1 overexpression was observed in 7 out of 38 (18%) esophageal SCCs and CCND1 overexpression was observed in 4 out of 38 (11%), suggesting that TAOS1 was more frequently overexpressed than CCND1 in esophageal SCC. The examination of the correlation of TAOS1 overexpression with the clinicopathological features revealed a significant difference in lymph node metastasis (p = 0.014) and a trend towards advanced TNM stages (p = 0.074).,The present results suggest that TAOS1 might serve as a new marker for predicting the malignancy of esophageal SCC.
语言:: eng
DOI:

文献库文献相关信息