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PMID: 1680676 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.

The EMBO journal ·Vol. 10 ·No. 11 ·1991-11-00 ·Pages 3147-55

Müller J, Bienz M

Abstract

In an attempt to reconstruct the embryonic expression pattern of the homeotic gene Ultrabithorax (Ubx) by stable integration of fusion constructs, we identified three key control regions called PBX, ABX and BXD. Each of these confers an expression pattern mimicking certain aspects of Ubx expression. The PBX and ABX patterns are limited to the Ubx domain with anterior boundaries at parasegments 6 and 5. In contrast, the BXD pattern extends from head to tail. PBX or ABX expression boundaries are imposed on the BXD pattern, if PBX or ABX is linked to BXD. These boundaries, although not the PBX and ABX expression limits themselves, are dependent on Polycomb function. We conclude that PBX and ABX are recognized by repressors which act across large distances to suppress BXD activity. Stable and heritable Ubx expression boundaries are thus mediated by this process of long range repression.

Related Genes
Pc Ubx
MeSH Terms
Animals Drosophila/embryology,genetics Genes, Homeobox Mutation Plasmids Regulatory Sequences, Nucleic Acid Restriction Mapping Transcription, Genetic beta-Galactosidase/metabolism
Chemicals
beta-Galactosidase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Müller J
Zoological Institute, University of Zürich, Switzerland.
Bienz M
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59 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1991-11-00
Pages
3147-55
Language
English
Region
England
NLM ID
8208664
PMCID
PMC453036
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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