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PMID: 16804116 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma.

Blood ·Vol. 108 ·No. 8 ·2006-10-15 ·Pages 2755-63

Chng WJ, Schop RF, Price-Troska T, Ghobrial I, Kay N, Jelinek DF, Gertz MA, Dispenzieri A, Lacy M, Kyle RA, Greipp PR, Tschumper RC, Fonseca R, Bergsagel PL

Abstract

Waldenström macroglobulinemia (WM) is a B-cell malignancy characterized by the ability of the B-cell clone to differentiate into plasma cells. Although the clinical syndrome and the pathologic characteristics are well defined, little is known about its biology and controversy still exists regarding its cell of origin. In this gene-expression study, we compared the transcription profiles of WM with those of other malignant B cells including (chronic lymphocytic leukemia [CLL] and multiple myeloma [MM]) as well as normal cells (peripheral-blood B cells and bone marrow plasma cells). We found that WM has a homogenous gene expression regardless of 6q deletion status and clusters with CLL and normal B cells on unsupervised clustering with very similar expression profiles. Only a small gene set has expression profiles unique to WM compared to CLL and MM. The most significantly up-regulated gene is IL6 and the most significantly associated pathway for this set of genes is MAPK signaling. Thus, IL6 and its downstream signaling may be of biologic importance in WM. Further elucidation of the role of IL-6 in WM is warranted as this may offer a potential therapeutic avenue.

MeSH Terms
Antigens, CD/genetics B-Lymphocytes/metabolism Cell Cycle/genetics Gene Expression Profiling Humans Interleukin-6/genetics Leukemia, Lymphocytic, Chronic, B-Cell/genetics MAP Kinase Signaling System/genetics Multiple Myeloma/genetics Phenotype Plasma Cells/metabolism Waldenstrom Macroglobulinemia/genetics
Chemicals
Antigens, CD Interleukin-6
Authors & Affiliations
14 authors, click to expand affiliations / ORCID
Chng Wee J
Department of Hematology-Oncology, Mayo Clinic Scottsdale, 13208 E Shea Blvd, Suite 300, Scottsdale, AZ 85259, USA.
Schop Roelandt F
Price-Troska Tammy
Ghobrial Irene
Kay Neil
Jelinek Diane F
Gertz Morie A
Dispenzieri Angela
Lacy Martha
Kyle Robert A
Greipp Philip R
Tschumper Renee C
Fonseca Rafael
Bergsagel Peter Leif
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Article Info
Journal
Blood
Abbr.
Blood
ISSN
0006-4971
DOI
10.1182/blood-2006-02-005488
Published
2006-10-15
Epub
2006-00-27
Pages
2755-63
Language
English
Region
United States
NLM ID
7603509
PMCID
PMC1895596
Subset
IM
Grants
NCI NIH HHS · CA 95241 · United States
NCI NIH HHS · P01 CA 62242 · United States
NCI NIH HHS · P50 CA 200707-01 · United States
NCI NIH HHS · R01 CA 83724-01 · United States
External Links
PubMed source DOI: 10.1182/blood-2006-02-005488 PMC Full Text View journal details
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