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PMID: 16800798 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Protein-peptide interaction studies demonstrate the versatility of calmodulin target protein binding.

Protein and peptide letters ·Vol. 13 ·No. 5 ·2006-00-00 ·Pages 455-65

Ishida H, Vogel HJ

Abstract

Calmodulin (CaM) is a prototypical Ca2+-sensor protein that can control many important biological functions by binding to hundreds of target proteins. To gain insight into the versatility of CaM-target recognition, we have analyzed the complex structures for many types of CaM-binding peptides and some target proteins. In particular, some recently reported novel complex structures reveal that the versatile target binding of CaM is accommodated by its flexible domain arrangement and the malleability of its interfaces.

MeSH Terms

Animals Calcium/metabolism Calcium-Calmodulin-Dependent Protein Kinase Kinase Calcium-Transporting ATPases/metabolism Calmodulin/chemistry,metabolism Calmodulin-Binding Proteins/metabolism Cell Membrane/metabolism Cytoskeletal Proteins/metabolism Glutamate Decarboxylase/metabolism Intracellular Signaling Peptides and Proteins/metabolism Membrane Proteins/metabolism Models, Molecular Myristoylated Alanine-Rich C Kinase Substrate Nerve Tissue Proteins/metabolism Nitric Oxide Synthase Type III/metabolism Peptides/genetics,metabolism Plant Proteins/metabolism Protein Binding Protein Conformation Protein Serine-Threonine Kinases/metabolism Sequence Analysis, Protein Small-Conductance Calcium-Activated Potassium Channels/metabolism Viper Venoms/metabolism

Chemicals

Basp1 protein, mouse Calmodulin Calmodulin-Binding Proteins Cytoskeletal Proteins Intracellular Signaling Peptides and Proteins Membrane Proteins Nerve Tissue Proteins Peptides Plant Proteins Small-Conductance Calcium-Activated Potassium Channels Viper Venoms edema factor Myristoylated Alanine-Rich C Kinase Substrate Nitric Oxide Synthase Type III Protein Serine-Threonine Kinases Calcium-Calmodulin-Dependent Protein Kinase Kinase Glutamate Decarboxylase Calcium-Transporting ATPases Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ishida Hiroaki

Structural Biology Research Group, Department of Biological Sciences, University of Calgary, Calgary, Alberta, T2N 1N4, Canada.

Vogel Hans J

Article Info

Journal

Protein and peptide letters

Abbr.

Protein Pept Lett

ISSN

0929-8665

DOI

10.2174/092986606776819600

Published

2006-00-00

Pages

455-65

Language

English

Region

Netherlands

NLM ID

9441434

Subset

External Links

PubMed source DOI: 10.2174/092986606776819600 View journal details

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Protein-peptide interaction studies demonstrate the versatility of calmodulin target protein binding.

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