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题目:: Cyclin D1 splice variant and risk for non-Hodgkin lymphoma.
作者:: Wang(Sophia S),Cozen(Wendy),Severson(Richard K),Hartge(Patricia),Cerhan(James R),Davis(Scott),Welch(Robert),Rothman(Nathaniel),Chanock(Stephen J)
状态:: 发布时间2006-08-11 , 更新时间 2007-12-03
期刊:: Hum Genet
摘要:: To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was consistent for four B-cell subtypes. As CCND1 expression indicates poor NHL prognosis, our results, if true, would support its potentially dual importance in NHL etiology and survival.
语言:: eng
DOI:: 10.1007/s00439-006-0212-3

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