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PMID: 16775359 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Active viremia in rotavirus-infected mice.

Journal of virology ·Vol. 80 ·No. 13 ·2006-07-00 ·Pages 6702-5

Blutt SE, Fenaux M, Warfield KL, Greenberg HB, Conner ME

Abstract

Rotavirus circulates extraintestinally in animals used as models for rotavirus infection and in children. Rotavirus infection in mice was used to define host or viral factors that affect rotavirus viremia. Antigenemia was observed with homologous and heterologous rotaviruses, and neither age nor mouse strain genetics altered the occurrence of rotavirus antigenemia or viremia. Rotavirus RNA and infectious virus were present in sera and associated with the plasma fraction of blood in all infected mice. These findings indicate that antigenemia/viremia occurs routinely in rotavirus infections and imply that infectious rotavirus has access to any extraintestinal cell within contact of blood.

MeSH Terms
Animals Antigens, Viral/blood,immunology Child Child, Preschool Disease Models, Animal Female Humans Mice RNA, Viral/blood,immunology Rotavirus/immunology Rotavirus Infections/blood,immunology Species Specificity Viremia/immunology
Chemicals
Antigens, Viral RNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Blutt Sarah E
Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Fenaux Martijn
Warfield Kelly L
Greenberg Harry B
Conner Margaret E
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.00329-06
Published
2006-07-00
Pages
6702-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC1488936
Subset
IM
Grants
NIAID NIH HHS · R01 AI024998 · United States
NIDDK NIH HHS · DK 56338 · United States
NIAID NIH HHS · R01 AI021362 · United States
NIAID NIH HHS · R37 AI021362 · United States
NIAID NIH HHS · AI 24998 · United States
NIAID NIH HHS · R21 AI024998 · United States
NIAID NIH HHS · AI 10604 · United States
NIDDK NIH HHS · P30 DK056338 · United States
NIAID NIH HHS · F32 AI010604 · United States
NIAID NIH HHS · AI 21362 · United States
NIAID NIH HHS · R56 AI021362 · United States
External Links
PubMed source DOI: 10.1128/JVI.00329-06 PMC Full Text View journal details
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