Acceleration of gluconeogenesis from lactate by lysine (Short Communication).

The Biochemical journal ·Vol. 134 ·No. 2 ·1973-06-00 ·Pages 671-2

Cornell NW, Lund P, Hems R, Krebs HA

Abstract

l-Lysine (2mm) causes an increase (mean 60%) in the rate of gluconeogenesis from lactate in isolated liver cells. The effect is of a catalytic nature. No other amino acid has the same effect, though ornithine is slightly active. The effect is additional to the stimulatory effects of oleate and of dibutyryl cyclic AMP.

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Cornell N W

Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, U.K.

Lund P

Hems R

Krebs H A

References (5)

5 references, click to expand

Control of gluconeogenesis in liver. II. Effects of glucagon, catecholamines, and adenosine 3',5'-monophosphate on gluconeogenesis in the perfused rat liver.
J Biol Chem. 1968 Aug 25;243(16):4189-96 PMID: 5679958
Carbohydrate metabolism of the perfused rat liver.
Biochem J. 1967 Nov;105(2):869-75 PMID: 5584023
Gluconeogenesis in the perfused rat liver.
Biochem J. 1966 Nov;101(2):284-92 PMID: 5966267
High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study.
J Cell Biol. 1969 Dec;43(3):506-20 PMID: 4900611
Rate control of the tricarboxylic acid cycle.
Adv Enzyme Regul. 1970;8:335-53 PMID: 4920378

Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1340671

Published

1973-06-00

Pages

671-2

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1177859

External Links

PubMed source DOI: 10.1042/bj1340671 PMC Full Text View journal details

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